@font-face{font-family:Hanken;src:url("./assets/hanken.woff2") format("woff2");font-style:normal;font-weight:100 900;font-display:swap}
:root{color-scheme:light;--ink:#172027;--crimson:#942e40;--sage:#e8efdc;--gold:#C99B5E;--paper:#f7f8f4;--white:#fff;--line:#dfe4dc;--muted:#69736e;--soft:#f0f3ed;--serif:Georgia,"Times New Roman",serif}
*{box-sizing:border-box}
html{scroll-behavior:smooth}
body{margin:0;background:var(--paper);color:var(--ink);font-family:Hanken,system-ui,sans-serif;font-size:16px;line-height:1.55;-webkit-font-smoothing:antialiased}
button,input,select,textarea{font:inherit;color:inherit}
button,a,select{-webkit-tap-highlight-color:transparent}
a{color:inherit}
.shell{width:min(1240px,calc(100% - 64px));margin-inline:auto}
.skip-link{position:absolute;z-index:10;top:-60px;left:16px;padding:10px 16px;background:var(--ink);color:white;border-radius:4px}.skip-link:focus{top:12px}
:focus-visible{outline:3px solid var(--crimson);outline-offset:3px}
[hidden]{display:none!important}
.site-header{height:84px;border-bottom:1px solid var(--line);background:rgba(255,255,255,.84)}
.header-inner{height:100%;display:flex;align-items:center;justify-content:space-between}
.brand{display:flex;align-items:center;gap:10px;color:var(--ink);font-size:18px;font-weight:650;letter-spacing:-.04em}.brand img{display:block;width:33px;height:33px;object-fit:contain}.brand-accent{color:var(--crimson)}
.header-note{display:flex;align-items:center;gap:9px;color:#5d6862;font-size:12px;font-weight:600;letter-spacing:.065em;text-transform:uppercase}.status-dot{width:7px;height:7px;border-radius:50%;background:#748b5e;box-shadow:0 0 0 4px #e8efdc}.header-divider{color:#b1b9b0}
.hero{position:relative;display:grid;grid-template-columns:minmax(0,1fr) 310px;align-items:end;gap:50px;padding:74px 0 54px}
.hero:after{position:absolute;content:"";right:285px;top:72px;width:158px;height:158px;border:1px solid rgba(148,46,64,.14);border-radius:50%;pointer-events:none}
.eyebrow,.section-kicker{font-size:10px;line-height:1.3;font-weight:750;letter-spacing:.16em;color:var(--crimson)}
.eyebrow{display:flex;align-items:center;gap:11px;margin:0 0 26px}
.eyebrow-mark{font-size:16px;color:var(--gold)}.eyebrow-line{width:29px;height:1px;background:var(--gold)}
h1{margin:0;font-size:clamp(54px,7vw,88px);line-height:.96;letter-spacing:-.067em;font-weight:620}
h1 em{font-family:var(--serif);font-weight:400;color:var(--crimson);letter-spacing:-.075em}
.hero-intro{max-width:500px;margin:24px 0 0;font-size:20px;line-height:1.5;color:#46514b}
.hero-meta{display:flex;align-items:center;gap:12px;margin-top:29px;color:var(--muted);font-size:12px}.meta-label{font-weight:700;color:var(--ink);letter-spacing:.04em;text-transform:uppercase}.meta-divider{width:24px;height:1px;background:var(--gold)}
.hero-aside{position:relative;z-index:1;padding:22px 23px 20px;background:var(--sage);border:1px solid #dce5d1;border-radius:3px 22px 3px 3px}
.aside-index{font-size:9px;letter-spacing:.14em;font-weight:750;color:#5d7050}.hero-aside p{font-family:var(--serif);font-size:18px;line-height:1.42;margin:16px 0 18px;color:#2b3831}.aside-rule{display:block;width:34px;height:2px;background:var(--gold);margin-bottom:12px}.aside-small{font-size:11px;color:#667366}
.notice{display:grid;grid-template-columns:34px 1fr auto;align-items:center;gap:14px;min-height:72px;padding:13px 20px;background:#fff;border:1px solid var(--line);border-left:3px solid var(--gold);border-radius:4px}
.notice-symbol{display:grid;place-items:center;width:25px;height:25px;border:1px solid #c4aa83;border-radius:50%;font-family:var(--serif);font-style:italic;color:#8c6940;font-size:15px}
.notice p{margin:0;font-size:13px;color:#47534c}
.notice-tag{font-size:9px;letter-spacing:.12em;font-weight:750;color:#677263;white-space:nowrap}
.evidence-key{display:grid;grid-template-columns:1fr minmax(250px,390px) 218px;align-items:center;gap:34px;padding:48px 0 43px;border-bottom:1px solid var(--line)}
.section-kicker{margin:0 0 8px}
h2{font-size:27px;line-height:1.15;letter-spacing:-.035em;font-weight:630;margin:0}
.key-body{font-size:13px;line-height:1.65;color:var(--muted);margin:0}
.key-chip{display:flex;align-items:center;gap:11px;padding:13px 14px;background:#f0f3ed;border:1px solid #dce3d8;border-radius:4px}
.key-dot{width:10px;height:10px;background:#748b5e;border-radius:50%;box-shadow:0 0 0 4px #e0e8d6;margin-left:2px}
.key-chip strong,.key-chip small{display:block}.key-chip strong{font-size:10px;letter-spacing:.09em}.key-chip small{font-size:10px;color:var(--muted);margin-top:2px}
.library{padding-top:48px}
.library-heading{display:flex;justify-content:space-between;align-items:end;gap:28px}
.library-tools{display:flex;gap:22px}
.text-action{display:inline-flex;align-items:center;gap:8px;padding:8px 0;border:0;background:transparent;color:#4b5850;font-size:12px;font-weight:650;cursor:pointer}
.text-action span{text-decoration:underline;text-decoration-color:#bec7bd;text-underline-offset:4px}
.text-action:hover{color:var(--crimson)}.text-action:disabled{opacity:.45;cursor:default}
.filters{display:grid;grid-template-columns:minmax(240px,1fr) 180px auto;gap:11px;align-items:center;margin:23px 0 15px}
.search-field,.filter-field{position:relative;display:flex;align-items:center;height:47px;background:#fff;border:1px solid #d9dfd7;border-radius:4px}
.search-field{gap:10px;padding:0 13px}.search-icon{font-family:var(--serif);font-size:23px;line-height:1;color:#849087;transform:rotate(-20deg)}
.search-field input{width:100%;height:100%;padding:0;border:0;outline:none;background:transparent;font-size:13px}
.search-field input::placeholder{color:#879087}
.search-field kbd{display:grid;place-items:center;width:21px;height:21px;border:1px solid var(--line);border-radius:3px;color:#848d86;font-size:10px}
.filter-field select{appearance:none;width:100%;height:100%;padding:0 38px 0 13px;border:0;background:transparent;font-size:12px;font-weight:600;cursor:pointer}
.select-chevron{position:absolute;right:13px;top:9px;color:#79857c;font-size:18px;pointer-events:none}
.result-count{min-width:110px;margin:0;color:var(--muted);font-size:11px;text-align:right}
.table-frame{overflow:hidden;border:1px solid #dce2da;border-radius:5px;background:#fff}
.topic-table{width:100%;border-collapse:collapse;table-layout:fixed}
.topic-table th{padding:13px 15px;background:var(--ink);color:#e7ebe7;text-align:left;font-size:9px;letter-spacing:.12em;font-weight:700}
.topic-table th:first-child{width:20%;padding-left:19px}.topic-table th:nth-child(2){width:25%}.topic-table th:nth-child(3){width:17%}.topic-table th:nth-child(4){width:38%}
.topic-table td{vertical-align:top;padding:18px 15px 19px;border-bottom:1px solid #e7ebe5;font-size:12px;line-height:1.55;color:#59645d}
.topic-table tbody tr:last-child td{border-bottom:0}
.topic-table tbody tr:hover td{background:#fbfcf9}
.topic-table td:first-child{padding-left:19px}
.compound-name{display:block;width:max-content;max-width:100%;font-family:var(--serif);font-size:19px;line-height:1.15;color:var(--ink);text-decoration-color:#bfc9bf;text-decoration-thickness:1px;text-underline-offset:4px}.compound-name:hover,.card-name:hover{color:var(--crimson);text-decoration-color:#c48490}
.compound-alias{display:block;margin-top:5px;color:#818b83;font-size:10px}
.category-label{display:inline-block;margin-top:9px;padding:3px 7px;background:var(--soft);border-radius:2px;color:#687663;font-size:9px;font-weight:650;letter-spacing:.04em}
.focus-copy{color:#48544c}
.evidence-label{display:inline-flex;align-items:center;gap:7px;padding:5px 8px;background:#f1f4ec;border:1px solid #e0e6d9;border-radius:2px;color:#55664b;font-size:9px;letter-spacing:.065em;font-weight:750}
.evidence-label:before{content:"";width:6px;height:6px;border-radius:50%;background:#82966e}
.study-summary{display:block;margin-top:9px;color:#657069}
.source-line{display:flex;flex-wrap:wrap;align-items:baseline;gap:6px;color:#5f6b63}
.source-link{color:var(--crimson);font-weight:700;text-decoration:underline;text-decoration-color:#d7aeb6;text-underline-offset:3px}
.source-year{font-size:10px;color:#838c85}
details.limit-detail{margin-top:8px}
.limit-detail summary{width:max-content;max-width:100%;color:#717c73;font-size:10px;cursor:pointer;text-decoration:underline;text-decoration-color:#c4ccc2;text-underline-offset:3px}
.limit-detail p{margin:7px 0 0;padding:8px 10px;background:#f7f8f4;border-left:2px solid #c6d1ba;color:#59645d;font-size:11px}
.topic-cards{display:none}
.empty-state{padding:47px 16px;text-align:center;background:#fff;border:1px solid var(--line);border-top:0}
.empty-glyph{font-family:var(--serif);font-size:33px;color:#abb5aa}
.empty-state h3{margin:5px 0;font-size:19px;font-weight:630}.empty-state p{margin:0 0 17px;color:var(--muted);font-size:12px}
.quiet-button{padding:8px 14px;border:1px solid var(--line);border-radius:4px;background:#fff;font-size:11px;font-weight:650;cursor:pointer}
.load-state{display:flex;align-items:center;justify-content:center;gap:10px;padding:42px;color:var(--muted);font-size:12px}
.load-spinner{width:15px;height:15px;border:2px solid #dce3d8;border-top-color:var(--crimson);border-radius:50%;animation:spin .8s linear infinite}
.load-state.error{display:block;text-align:center;color:#7b3441;background:#fff;border:1px solid #ead9dc;border-radius:4px}
@keyframes spin{to{transform:rotate(360deg)}}
.glossary{display:grid;grid-template-columns:245px 1fr;gap:34px;padding:55px 0 53px;border-bottom:1px solid var(--line)}
.glossary-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:13px}
.glossary-item{padding:13px 15px;background:#fff;border:1px solid #e2e7df;border-radius:3px}
.glossary-item dt{font-family:var(--serif);font-size:16px;color:#29372f}
.glossary-item dd{margin:5px 0 0;color:#69746c;font-size:11px;line-height:1.5}
.glossary-placeholder{grid-column:1/-1;margin:0;color:var(--muted);font-size:12px}
.question-prompt{display:grid;grid-template-columns:48px 1fr auto;align-items:center;gap:19px;margin:50px 0 27px;padding:24px 27px;background:#fff;border:1px solid #dfe5dc;border-radius:4px}
.prompt-mark{display:grid;place-items:center;width:43px;height:43px;border-radius:50%;background:var(--sage);color:#61724f;font-size:19px}
.prompt-copy .section-kicker{margin-bottom:5px}
.prompt-copy h2{font-family:var(--serif);font-size:22px;font-weight:400;letter-spacing:-.02em}
.prompt-copy>p:last-child{margin:5px 0 0;color:var(--muted);font-size:11px}
.prompt-actions{display:grid;justify-items:center;gap:6px}
.button{display:inline-flex;align-items:center;justify-content:center;gap:16px;min-height:43px;padding:10px 17px;border:1px solid transparent;border-radius:3px;text-decoration:none;font-size:11px;font-weight:700;cursor:pointer}
.button-dark{background:var(--ink);color:#fff}.button-dark:hover{background:var(--crimson)}
.copy-status{min-height:14px;color:#647353;font-size:10px}
.visually-hidden{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border:0}
.next-step{display:flex;align-items:center;justify-content:space-between;gap:24px;padding:20px 0 29px;border-top:1px solid var(--line)}
.next-label{font-size:9px;letter-spacing:.13em;font-weight:750;color:var(--crimson)}
.next-step p{margin:4px 0 0;color:#606c64;font-size:12px}
.homepage-link{display:inline-flex;align-items:center;gap:12px;padding:10px 0;color:var(--ink);font-size:11px;font-weight:700;text-decoration:underline;text-decoration-color:#b4beb3;text-underline-offset:4px}.homepage-link span{color:var(--crimson)}
.site-footer{border-top:1px solid var(--line);background:#f0f2ed}
.footer-inner{min-height:75px;display:flex;align-items:center;justify-content:space-between;gap:22px}
.footer-brand{display:inline-flex;align-items:center;gap:7px;color:var(--ink);font-size:13px;font-weight:650;letter-spacing:-.035em;white-space:nowrap}.footer-brand img{width:23px;height:23px}.footer-note{font-size:10px;color:#59665d;white-space:nowrap}
.footer-inner p{max-width:580px;margin:0;color:#778078;font-size:10px;text-align:center}
 .pdf-download{white-space:nowrap}
.toast{position:fixed;z-index:5;right:24px;bottom:22px;max-width:min(380px,calc(100vw - 32px));padding:12px 16px;background:var(--ink);color:#fff;border-radius:3px;box-shadow:0 12px 35px #17202724;font-size:12px;opacity:0;transform:translateY(8px);pointer-events:none;transition:opacity .2s,transform .2s}
.toast.visible{opacity:1;transform:translateY(0)}
@media(min-width:1400px){.hero{padding-top:87px;padding-bottom:65px}}
@media(max-width:900px){.shell{width:min(100% - 44px,760px)}.hero{grid-template-columns:minmax(0,1fr) 250px;gap:28px;padding:58px 0 43px}.hero:after{right:216px;width:120px;height:120px}.hero-aside{padding:18px}.hero-aside p{font-size:16px}.evidence-key{grid-template-columns:1fr 1fr;gap:17px 24px}.key-chip{grid-column:2;grid-row:1 / span 2}.topic-table th:first-child{width:21%}.topic-table th:nth-child(2){width:23%}.topic-table th:nth-child(3){width:18%}.topic-table th:nth-child(4){width:38%}.topic-table td{padding-inline:11px}.topic-table td:first-child{padding-left:14px}.compound-name{font-size:17px}.glossary{grid-template-columns:180px 1fr;gap:22px}.glossary-grid{grid-template-columns:repeat(2,1fr)}}
@media(max-width:640px){.shell{width:calc(100% - 36px)}.site-header{height:70px}.brand{font-size:16px}.brand img{width:30px;height:30px}.header-note{font-size:9px;gap:7px}.header-divider{display:none}
.hero{display:block;padding:47px 0 29px}.hero:after{top:48px;right:1px;width:86px;height:86px}.eyebrow{font-size:8px;gap:7px;margin-bottom:22px}.eyebrow-line{width:18px}.eyebrow-mark{font-size:13px}h1{font-size:clamp(52px,15vw,72px)}.hero-intro{position:relative;z-index:1;max-width:340px;margin-top:17px;font-size:16px}.hero-meta{margin-top:18px;font-size:10px}.hero-aside{margin-top:25px;padding:15px 17px;display:grid;grid-template-columns:1fr auto;align-items:start;gap:0 15px}.aside-index{grid-column:1/-1}.hero-aside p{margin:8px 0 0;font-size:15px}.aside-rule{display:none}.aside-small{align-self:end;max-width:90px;text-align:right;font-size:9px}
.notice{grid-template-columns:27px 1fr;gap:10px;padding:12px 13px}.notice p{font-size:11px}.notice-tag{grid-column:2;font-size:8px}.notice-symbol{width:22px;height:22px}
.evidence-key{grid-template-columns:1fr auto;gap:12px;padding:35px 0 29px}.key-heading h2{font-size:23px}.key-body{grid-column:1/-1;grid-row:2;max-width:450px;font-size:12px}.key-chip{grid-column:2;grid-row:1;padding:10px}.key-chip small{max-width:115px;font-size:9px}.key-chip strong{font-size:8px}
.library{padding-top:35px}.library-heading{align-items:start;display:block}.library-heading h2{font-size:24px}.library-tools{flex-wrap:wrap;gap:7px 16px;margin-top:10px}.text-action{font-size:10px}.filters{grid-template-columns:1fr 130px;margin:17px 0 9px}.search-field{grid-column:1/-1;height:44px}.filter-field{height:42px}.result-count{grid-column:2;grid-row:2;min-width:0;text-align:right;font-size:10px}
.table-frame{display:none}.topic-cards{display:grid;gap:10px}.topic-card{padding:15px 15px 13px;background:#fff;border:1px solid #dfe4dc;border-radius:4px}.card-head{display:flex;justify-content:space-between;gap:12px;align-items:start}.card-name{display:block;width:max-content;max-width:100%;font-family:var(--serif);font-size:19px;line-height:1.15;color:var(--ink);text-decoration:underline;text-decoration-color:#bfc9bf;text-underline-offset:4px}.card-alias{display:block;margin-top:3px;color:#808a82;font-size:10px}.card-category{flex:0 0 auto;padding:3px 7px;background:#f0f3ed;color:#65735e;border-radius:2px;font-size:8px;font-weight:700}
.card-focus{margin:12px 0 13px;color:#4c5851;font-size:11px;line-height:1.5}.card-divider{height:1px;background:#e8ece6;margin-bottom:11px}.card-bottom{display:flex;align-items:flex-start;justify-content:space-between;gap:11px}.card-bottom .evidence-label{flex:none;padding:4px 6px;font-size:8px}.card-study{margin:8px 0 0;color:#667169;font-size:10px;line-height:1.45}.card-source{margin:0;color:#667169;font-size:10px;line-height:1.4}.card-details{margin-top:9px}.card-details summary{color:#758076;font-size:10px;cursor:pointer;text-decoration:underline;text-underline-offset:3px}.card-details p{margin:6px 0 0;padding:8px;background:#f7f8f4;border-left:2px solid #c6d1ba;font-size:10px;color:#59645d}
.glossary{display:block;padding:37px 0 34px}.glossary-heading h2{font-size:23px}.glossary-grid{margin-top:16px;grid-template-columns:1fr 1fr;gap:9px}.glossary-item{padding:11px}.glossary-item dt{font-size:14px}.glossary-item dd{font-size:10px}
.question-prompt{grid-template-columns:37px 1fr;gap:10px 13px;margin:33px 0 17px;padding:16px}.prompt-mark{width:35px;height:35px;font-size:16px}.prompt-copy h2{font-size:19px}.prompt-copy>p:last-child{font-size:10px}.prompt-actions{grid-column:2;justify-items:start}.button{min-height:40px}
.next-step{padding:17px 0 22px}.next-step p{max-width:240px;font-size:10px}.homepage-link{font-size:10px;white-space:nowrap}
.footer-inner{min-height:83px;flex-wrap:wrap;justify-content:space-between;gap:6px 12px;padding-block:13px}.footer-brand{font-size:11px}.footer-brand img{width:19px;height:19px}.footer-note{font-size:8px}.footer-inner p{order:3;flex:0 0 100%;text-align:left;font-size:9px}
}
@media(max-width:370px){.header-note{max-width:112px;line-height:1.2}.filters{grid-template-columns:1fr 112px}.key-chip{padding:8px}.key-chip small{max-width:100px}.homepage-link{gap:6px}}
@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}*,*:before,*:after{animation-duration:.01ms!important;animation-iteration-count:1!important;transition-duration:.01ms!important}}
@media print{
  @page{size:auto;margin:14mm}
  :root{--paper:#fff}
  body{background:#fff;font-size:10pt;color:#111}
  .shell{width:100%;max-width:none}
  .site-header{height:auto;border-bottom:1px solid #999}.header-inner{padding:0 0 8mm}.brand{font-size:15pt}.brand img{width:28px;height:28px}
  .header-note,.hero:after,.hero-aside,.library-tools,.filters,.question-prompt,.site-footer,.toast,.skip-link{display:none!important}
  .hero{display:block;padding:10mm 0 7mm}.eyebrow{margin-bottom:6mm}h1{font-size:37pt}.hero-intro{font-size:13pt;margin-top:5mm}.hero-meta{margin-top:4mm}
  .notice{min-height:0;padding:4mm;border:1px solid #bbb}.notice-tag{display:none}
  .evidence-key{grid-template-columns:1fr 1fr 190px;padding:8mm 0;gap:6mm}.key-chip{grid-column:auto;grid-row:auto}
  .library{padding-top:8mm}.library-heading{padding-bottom:4mm}.library-heading h2,.glossary-heading h2{font-size:19pt}
  .table-frame{display:block!important;overflow:visible;border-color:#aaa}.topic-table{table-layout:fixed}.topic-table th:first-child{width:20%}.topic-table th:nth-child(2){width:18%}.topic-table th:nth-child(3){width:31%}.topic-table th:nth-child(4){width:31%}.topic-table tr{break-inside:avoid}.topic-table th{background:#e8ece6!important;color:#111;padding:3mm;font-size:7pt}.topic-table td{padding:3mm;font-size:8pt;color:#333;break-inside:avoid}.compound-name{font-size:12pt}.topic-cards{display:none!important}
  .source-link{color:#111}.limit-detail[open] p{display:block}.limit-detail summary{display:none}.limit-detail p{background:#fff;padding:2mm;font-size:7.5pt}
  .glossary{display:block;padding:5mm 0;border-color:#aaa;break-inside:avoid}.glossary-grid{grid-template-columns:repeat(4,1fr);gap:2mm;margin-top:3mm}.glossary-item{padding:2mm;margin:0}.glossary-item dt{font-size:9pt}.glossary-item dd{font-size:7.5pt}.next-step{break-inside:avoid;padding:3mm 0}.next-step p,.homepage-link{font-size:8pt}
  .load-state,.empty-state{display:none!important}
  a{text-decoration:none}
}

.study-label-note{margin:7px 0 0;color:var(--muted);font-size:12px}.library+.notice{margin-top:28px}

/* Full catalog and source-described research detail */
.filters{grid-template-columns:minmax(220px,1fr) 165px 145px auto}
.topic-table th:first-child{width:22%}.topic-table th:nth-child(2){width:18%}.topic-table th:nth-child(3){width:30%}.topic-table th:nth-child(4){width:30%}
.variant-list{display:grid;gap:5px;margin-top:12px}
.variant-link,.variant-unavailable{display:block;width:max-content;max-width:100%;font-size:10px;line-height:1.4}
.variant-link{color:var(--crimson);font-weight:700;text-decoration:underline;text-decoration-color:#d7aeb6;text-underline-offset:3px;overflow-wrap:anywhere}
.variant-unavailable,.source-unavailable{color:#7a847c;font-size:10px}
.protocol-summary-list{display:grid;gap:11px}
.protocol-summary{display:grid;gap:3px;padding-left:9px;border-left:2px solid #d7dfcf}
.protocol-summary-label{font-family:var(--serif);font-size:14px;line-height:1.25;color:#27332c}
.protocol-summary-copy{color:#46534a;font-size:11px}
.protocol-summary-type{color:#829077;font-size:9px;letter-spacing:.06em;text-transform:uppercase}
.row-details{margin-top:10px}
.row-details summary{width:max-content;max-width:100%;color:#69756d;font-size:10px;cursor:pointer;text-decoration:underline;text-decoration-color:#c4ccc2;text-underline-offset:3px}
.details-body{margin-top:8px;padding:10px;background:#f7f8f4;border-left:2px solid #c6d1ba;color:#59645d;font-size:10px}
.details-body>p{margin:0}
.protocol-note+.protocol-note{margin-top:12px;padding-top:11px;border-top:1px solid #dfe5dc}
.protocol-note h4{margin:0 0 5px;color:#303c34;font-family:var(--serif);font-size:14px;font-weight:500}
.protocol-type{display:inline-block;margin-bottom:6px;color:#829077;font-size:9px;letter-spacing:.07em;text-transform:uppercase}
.protocol-fields{display:grid;grid-template-columns:minmax(95px,auto) 1fr;gap:3px 10px;margin:5px 0 8px}
.protocol-fields dt{color:#7a857c;font-size:9px;font-weight:700;text-transform:uppercase;letter-spacing:.04em}
.protocol-fields dd{margin:0;color:#46534a;overflow-wrap:anywhere}
.protocol-source{margin-top:7px}
.protocol-note p{margin:6px 0;color:#59645d}
.protocol-note ul{margin:5px 0 0;padding-left:17px}
.protocol-note li+li{margin-top:4px}
.card-variants{grid-template-columns:repeat(2,minmax(0,1fr));gap:6px 10px}
.card-evidence{display:grid;gap:6px;margin-top:8px}
.card-evidence .card-study{margin:0}
.card-protocols{display:grid;gap:7px;margin:6px 0;padding:9px 10px;background:#f7f8f4;border-left:2px solid #c6d1ba}
.card-protocol{margin:0;color:#48544c;font-size:10px;line-height:1.45}
.card-protocol strong{font-weight:700;color:#26332b}
.study-label-note{max-width:600px}
@media(max-width:900px){.filters{grid-template-columns:minmax(200px,1fr) 145px 135px auto}.topic-table th:first-child{width:22%}.topic-table th:nth-child(2){width:17%}.topic-table th:nth-child(3){width:31%}.topic-table th:nth-child(4){width:30%}.topic-table td{padding-inline:9px}}
@media(max-width:640px){
  .filters{grid-template-columns:1fr 1fr;gap:8px}.search-field{grid-column:1/-1}.filter-field{height:42px}.result-count{grid-column:1/-1;grid-row:auto;text-align:left;padding:2px 0 1px}
  .card-variants{grid-template-columns:1fr 1fr}.card-protocols{margin:5px 0 0}
  .protocol-fields{grid-template-columns:88px 1fr;gap:3px 7px}
}
@media print{
  .filters{display:none!important}.topic-table th:first-child,.topic-table th:nth-child(2),.topic-table th:nth-child(3),.topic-table th:nth-child(4){width:auto}
  .topic-table th:first-child{width:20%}.topic-table th:nth-child(2){width:17%}.topic-table th:nth-child(3){width:35%}.topic-table th:nth-child(4){width:28%}
  .variant-link,.source-link{color:#111;text-decoration:underline;overflow-wrap:anywhere}
  .variant-list{gap:1mm;margin-top:2mm}.variant-link{font-size:7pt}
  .row-details summary{display:none}.details-body{display:block!important;background:#fff;padding:2mm;font-size:7pt}.protocol-note+.protocol-note{margin-top:2mm;padding-top:2mm}
  .protocol-note h4{font-size:9pt}.protocol-fields{grid-template-columns:24mm 1fr}.protocol-fields dt,.protocol-type{font-size:6.5pt}
  .protocol-summary{break-inside:avoid}.topic-table tr{break-inside:avoid}
}

.math-panel{padding:28px 0;border-bottom:1px solid var(--line)}.math-panel>p{font-size:13px;color:var(--muted);max-width:780px}.math-panel form{display:grid;grid-template-columns:1fr 1fr 1fr auto;gap:12px;align-items:end}.math-panel label{font-size:12px;font-weight:650}.math-panel input{display:block;width:100%;padding:10px;margin-top:5px;background:white;border:1px solid var(--line);border-radius:4px}.math-panel #concentration-result{font-weight:650;color:var(--ink)}@media(max-width:640px){.math-panel form{grid-template-columns:1fr 1fr}.math-panel .button{align-self:end}}@media print{.math-panel{display:none!important}}
.summary-source{font-size:9px;margin-top:3px}.summary-source .source-link,.summary-source .source-unavailable{font-size:9px}.protocol-warning{display:block;margin:4px 0 0;font-size:10px;color:#813647;line-height:1.5}.protocol-summary-copy,.protocol-fields dd,.protocol-note>p{white-space:pre-line}
.question-prompt textarea:not(.visually-hidden){grid-column:1/-1;width:100%;min-height:150px;padding:12px;border:1px solid var(--line);border-radius:4px;background:#fff;font-size:12px;resize:vertical}
@media(max-width:640px){.topic-cards,.topic-card{min-width:0}.card-head>div{min-width:0;flex:1}.card-category{max-width:100px;white-space:normal}.card-evidence,.card-protocols{min-width:0;overflow-wrap:anywhere}}
.card-variants .variant-link,.card-variants .variant-unavailable{width:100%;min-width:0;overflow-wrap:anywhere}